I’ve been making my own DIY liposomal glutathione for a little bit now. I’m no expert, but I’ve done quite a bit of research to try and make it right. Because it’s hard to find one place online for complete instructions, I have put them here. I tried to keep it short and sweet. If you want to read more, I made some notes at the bottom.

EDIT: I have tried blending for a few minutes instead of using the ultrasonic cleaner (below) and it still helped me. But I included the original instructions as they adhere to common advice for making DIY liposomal supplements.

Order supplements through my Fullscript store.

What you need to make liposomal glutathione

  • Sunflower lecithin (don’t go with soy for the obvious reasons)
  • Reduced glutathione powder from Bulk Supplements on Amazon
  • A commercial ultrasonic cleaner that will run continuously for up to 30 minutes. I have used this one because it was recommended by another DIY glutathione maker. Do not get the smaller, cheaper ones because it will only make a small amount and you’ll have to sit there hitting the on button every two minutes. NEW! You can now buy an ultrasonic cleaner with a beaker holder – made specifically for making liposomal solutions!
  • A borosilicate flask (I got a one for coffee by Bodum at a kitchen store. Don’t let the scienc-y term put you off, it’s just a glass container used for coffee and in labs)
  • Distilled water
  • A hand blender
  • A whisk
  • Ice
  • A funnel
  • A sturdy, attractive container to show off your inflammation-fighting brew. I use a thick glass beer type bottle with a rubber pop top. And because I’m one of those people who just takes a swig a few times a day.

Instructions for making DIY Gluathione

I like things to be as quick and easy as possible, so I will simplify a procedure if it seems overly complicated. I have made my DIY liposomal glutathione the way the instructions say to and my way, and I get the same autoimmune taming effects from both. Some people are sticklers for exact details, in which case my method might not be for you :p.

Basically, remember this simple formula so you can make larger batches (I make a triple batch — these instructions are for a single batch).

  • 3 Tbs of sunflower lecithin per cup of water
  • 1 Tb of reduced glutathione per half cup of water


1) Add one cup of distilled water and add three Tb of sunflower lecithin to your glass flask. Blend thoroughly with your hand blender. (If you don’t have a hand blender just whisk as good as you can.)

2) Place a folded paper towel in the bottom of your ultrasonic cleaner, with the basket removed. Set the flask on top of the towel, and then fill the cleaner with water around the flask.

Why a paper towel? Because it dampens the horrible vibrating sound of the flask against the metal. Also, I make the DIY liposomal glutathione in a flask because one site said the ultrasonic cleaner will leach metal into your mixture.

3) If you were not able to use a hand blender for your sunflower lechithin mixture, run your ultrasonic cleaner for 20-30 minutes to help it blend better.

4) Mix 1 Tb of reduced glutathione in a 1/2 cup of distilled water and whisk thoroughly. Add to the lecithin mix.

Last time I skipped mixing it separately and just dumped the water and glutathione into the lecithin, then zapped it good with the hand blender. Seemed to work fine, but if you don’t have a hand blender you may want to whisk it first.

5) After you’ve got your complete mix in the flask, set your ultrasonic cleaner to 30 minutes and begin the process. Check in and whisk it occasionally.

Run it in the ultrasonic cleaner until there is no foam on the surface. I make a triple batch and need to run it multiple times.

Because I make a triple batch the level of the mixture in the flask is slightly above the level of water in the ultrasonic cleaner. At some point I’ll look into getting an even bigger cleaner if they make them. I don’t know if this affects the quality, doesn’t seem to. I think the vibration is getting to the entire batch.

6) Check the temperature of the water in the cleaner and your mix if you have to run it multiple times as it will start to get hot. Add ice to the water to keep the mixture cool — another reason to use the flask. Let it rest if need be.

7) Your DIY liposomal glutathione is said to be complete when there is no more foam on the surface of the mix. With my triple batch this can take 4-6 runs on the half-hour setting.

8) Use the funnel to pour your mix into your bottle and store in the refrigerator. You just saved oodles of money!

How much of your DIY liposomal glutathione do you take?

Dr. Kharrazian says to take as much as you need to put out your fire. It depends on your degree of inflammation. I take a swig two to three times a day — more when I’m having a flare, less when I’m not.

DIY glutathione not as concentrated as store-bought

I have learned this: From looking at the amount of reduced glutathione in the DIY mix compared to liposomal glutathione you buy online, the professional mixes appear to be about three times as concentrated. So if you are used to drinking store bought, you may need to up your dose.

Start with small doses to be safe

It’s safest to always start with small doses and work your way up in case you have adverse effects. Some people have sulfation issues and can’t tolerate it.

When you don’t have access to your DIY liposomal glutathione

When I’m traveling I buy s-acetyl-glutathione from Apex Energetics and take about five to twelve capsules a day, which gets expensive, so I drink the liposomal glutathione at home. Update: I just tried this glutathione spray from Amazon and it seems to work. And the price isn’t too bad.

I also take a product called Glutathione Recycler from Apex Energetics, which has a variety of glutathione precursors in it.

One person told me taking glutathione would shut down my body’s ability to make its own. It is not a hormone so that does not make sense to me. I also asked Dr. Kharrazian and he said he has never heard that. If you have evidence please let me know. We are bombarded with toxins and stressors on a daily basis that tax our glutathione system. I think it is an amazing preventive strategy. I know my body sure has responded positively to it.

DIY glutathione notes I have picked up along the way

–Some people say this method does not make truly liposomal glutathione, it’s just emulsified. Apparently you can only verify in a lab. But I don’t care. It either works or it doesn’t.

–Lecithin can be good brain support in itself. I haven’t researched it much, but I know it helps cellular membranes. However, I believe it can be unstable, so use your batches up quickly. I make a triple batch about once a week.

–I came across one source that said just making your DIY liposomal glutathione with a hand blender (and skipping the ultrasonic cleaner) might be good enough. This has worked for me actually.

–Most DIY liposomal sites are for vitamin C, which many people report benefits them greatly. I have psoriasis so cannot use vitamin C as it affects a mechanism that triggers a psoriasis flare. I don’t remember specifically what, but I’m sure it can be found online.

–From what I can tell, you use the same amount of reduced glutathione as ascorbic acid in the DIY liposomal C recipes.

–You can make other things liposomal! People make DIY liposomal carnitine, CoQ10, resveratrol, turmeric, milk thistle, etc. If you respond well to a supplement and want to save  money, order it in bulk and see if this method works for you.

–I used to purchase from this doomsday prepper company on eBay. They make all kinds of liposomal products. My hunch is it’s roughly the same process. Their glutathione always worked well for me and they’re very nice. And they’re products are much cheaper than the professional brands. If things are too hectic for me to make my own it’s an affordable backup with that DIY feel.

If you want to totally geek out on DIY liposomal making

I love this site below, it is so detailed, descriptive, and precise. I’ll never follow through but I would love to hear from someone who does.

It’s called Quality Liposomal Vitamin C.

Measurements are in ml and it was put together by someone who has access to a lab. It’s a good site for the science geeks.

Protect your body from modern life with DIY liposomal glutathione!

I hope this helps. I’m kind of loose with directions, which makes some people crazy.

But many autoimmune and brain-compromised people get overwhelmed easily. So I hope my instructions make the process easier for you and will help you save money and protect yourself from the inflammatory arrows of modern life!




35 Comments. Leave new

  • Do you know if this could be used transdermally? Or does the commercial transdermal glutathione have some other quality that makes it work transdermally?

  • I have done the Quality Liposomal recipe. I was hesitant to use alcohol as the recipe calls for but after tinkering a bit, my product seems quite good. I mix Acerola & Ascorbic Acid, a little Baking Soda to buffer the Ascorbic Acid, Glutathione, Trans-Resveratrol, Curcumin, a little Piperline and of course mechanically extracted liquid Sunflower Lecithin. Filling the Beakers to below the Ultrasonic water line helps to transfer more power into the solution.

    • Functional Health News
      September 1, 2016 7:55 pm

      Would you be willing to share a more exact recipe? I have heard of using alcohol. Or would you like to write a guest blog article? Please let me know as I would love to have the information to try myself and to share!

  • I would like to have concise measurements of all of the ingredients, please.

  • Marcella Pope
    May 6, 2020 3:16 pm

    I am hesitant to used bottled distilled water because of the toxins from plastic. Is there another way?

    • Functional Health News
      June 13, 2020 10:02 pm

      I agree, I have the same concerns. You could buy a water distiller. I’m not sure if boiling would be sufficient.

  • Dennis Elucidatus
    May 28, 2020 6:24 am

    Could I use an electric blender on low, rather than a hand blender? I do the qualityliposomalc recipe and it works great.

  • Quality liposomal vitamine C site is great I made it several time, excellent.
    With your condition you should try hyperbaric treatment or EWOT.

  • Can Liposomal Supplements be used directly?

  • Sorry that should have said. Can it be used rectally ?

    • Functional Health News
      July 7, 2020 10:22 pm

      I have found sites online on making your own suppositories but I’m not sure you’d be able to absorb enough that way with this recipe.

  • Will Coffee enema stimulate liver in producing more glutathione?

    • Yes

    • Functional Health News
      September 15, 2020 4:11 pm

      That is the story, but truth be told when I tried to verify this I was not able to find any studies confirming. So I don’t think it’s a proven point, though I’m certainly open to sharing the science if there is any.

  • Have you heard of sublingual glutathione, made with avocado kernel? the avocado core is rich in glutathione. The recipe for extracting glutathione from avocado seed uses cereal alcohol (used to make wisk, vodka ..)

  • are you using liquid or powder lecithin?

  • hello,

    This is fascinating – thank you.

    I have been making liposomal vit c for a while now, following various recipes. I wish I had a microscope so I could see the liposomaes. Then I’d be happy. But I did do a test (which I can’t find now) using bicarbonate of soda. It tested for acidity levels and obviously lower levels pointed to greater encapsulation – it was very satisfying.

    I digress, though, because as well as trying your glutathione idea, I wonder if anyone has encapsulated collagen. This is also very expensive to buy and I’d love to have a go.

    Thanks again for your very interesting post.

    Best wishes,


  • I am sensitive to sunflower…what can I substitute?

  • Have you tried making this recipe in a suppository? I read that you absorb more. I have seen on youtube people making it but with powder only not in liposomal form. Thanks!

  • you say in your article that the professionally made lipo-glutathione is 3 times AS effective as the homemade, then you say that if you are taking the store bought kind you may need to up your dose. A contradiction. Do you mean that the store bought is 3x less effective? Unclear here. thanks.

    • I took it to mean that if you make your own liposomal glutathione but were used to taking the store bought one, you should take 3x the amount of your homemade.

  • Thank you for this wonderful recipe. But I don’t know exactly how many Ml CUP means. When I look it up on Google, it says 1CUP=250ml. Would this be right?

  • The precursor to Gluthanoine is a supplement called NAC N-acetylcysteine , which
    When consumed, gets absorbed in the gastrointestinal tract, sent to the liver, and converted to cysteine.8 The liver uses cysteine to produce glutathion

  • Dr Daniel DeBrouse
    November 23, 2021 3:34 am

    Hi, I’m Dr Daniel DeBrouse, I like your procedure, great work. And pay no attention to anyone who says your not producing true liposomal glutathione. You most certainly are. See most have an impossible time understanding ultrasonics. You have sound waves making 20,000-100,000 vibrations per second in ultrasonic cleaners. That is more than sufficient for the generation of liposomal glutathione. Just imagine a cell hit but such over just one 30min period. Most fail to realize sound waves have tremendous potential to do work. I held the first patents behind using ultrasonics to fuel chemical reactions. Anyway I want to tell you when you have psoriasis flare up take CBD powder and formulate a skin lotion after one application the flare up gone completely every trace. I’ve seen this time and time again.

  • do u recon it is better to use sodium ascorbe instead of ascorbic acid because of the acidity?…maybe easier to use instead of putting bicarb in the mixture?
    Also do u think u can make a liposomal of cbd tincture u mix in the alcohol content?

  • I have used both ascorbic acid and sodium ascorbate and have observed equivalent effects. Ascorbate is easier to deal with, no buffering needed – it just requires twice as much powder as pure ascorbic acid.

  • Hi there,
    Can this recipe be stored in the freezer – I tripled the quantity and now I have a big amount and considering how little one takes daily I’m really hoping I can!

  • I came across your post and really like the information you give. The link to the quality liposomal vitamin c does not work. I know the post is old however, I’m wondering if you still have the website address or at least the name of the site. It looked like it maybe helpful.

  • Get tired of the fly by night type of articles that quit answering questions from people seeking important answers. Either get treatment for ADD. Or treatment for responsible commitment.

  • Loved this blog! Thank you so much for the information in a quick every day use kind of way ! Right up my alley! …
    I have been making liposomal C for a few months now and am so happy about our results for the whole family!.. I’m ready to make more things and will use your recipe. .. I basically do the same thing for c as you have described. Adding 2 tbls of clear cheap vodka ups the potency of all liposomal at home made products. It’s totally safe! Please there’s alchohol in every medicine sold in cvs and we don’t blink an eye. .. and yes I agree with another reader who said to keep your product closer to the water line to get better absorption. But at the end of the day- if your body responds and feels good- then you’re doing something right! Good job. Let’s stay strong at home folks 🙂 God bless

  • claudia van roosmalen
    December 28, 2022 10:47 am

    Dr Daniel DEBrouse: This CBD remedy sounds amazing! Could you please explain: What quantity of cbd powder do you use and how do you make it into a body lotion for psoriasis? THANK YOU 🙂


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